Table 1.
Examples of miRNA downregulated in CVDs with potential connection on pyroptosis.
| Human inflammasome component (NCBI RefSeq) |
miRNAs predicted by *TargetScan and reported to be downregulated in CVDs | Related CVDs [reference] |
|---|---|---|
| NLR proteins (NODs) | ||
| NOD1 (NM_006092) | miR-1 | DCM, AS [45], MI [46], LVH [47] |
| miR-133 | MI [46], LVH [47] | |
| miR-208 | MI [46] | |
| miR-499 | AS [45], MI [46] | |
| NOD2 (NM_022162) | miR-30e-5p | DCM, AS [45] |
| miR-208 | MI [46] | |
| miR-499 | AS [45], MI [46] | |
| NOD3/NLRC3 (NM_178844) | miR-10 | AS [45] |
| miR-24 | MI [59, 60] | |
| NOD4/NLRC5 (NM_032206) | miR-21 | MI [61] |
| NOD5/NLRX1 (NM_024618) | miR-24 | MI [59, 60] |
| miR-133 | MI [46], LVH [47] | |
| CIITA (NM_000246) | miR-10 | AS [45] |
| miR-24 | MI [59, 60] | |
| NLR proteins (NOD-like receptor family pyrin domain containing, LNRPs) | ||
| NLRP1 (NM_014922) | miR-10 | AS [45] |
| NLRP2 (NM_017852) | No miRNA meets the screening criteria | |
| NLRP3 (NM_004895) | miR-17-5p | DCM [45] |
| miR-30e-5p | DCM, AS [45] | |
| NLRP4 (NM_134444) | No miRNA meets the screening criteria | |
| NLRP5 (NM_153447) | No miRNA meets the screening criteria | |
| NLRP6 | Prediction data not available | |
| NLRP7 (NM_139176) | miR-150 | MI [62] |
| NLRP8 (NM_176811) | miR-155 | MI [62], LVH [63] |
| NLRP9 (NM_176820) | miR-19 | DCM, AS [45] |
| NLRP10 | Prediction data not available | |
| NLRP11 (NM_145007) | No miRNA meets the screening criteria | |
| NLRP12 (NM_033297) | No miRNA meets the screening criteria | |
| NLRP13 | Prediction data not available | |
| NLRP14 (NM_176822) | miR-1 | DCM, AS [45], MI [46], LVH [47] |
| NLR proteins (ice protease-activating factor (IPAF)) | ||
| NLRC4 (NM_021209) | No miRNA meets the screening criteria | |
| NAIP (NM_004536) | miR-1 | DCM, AS [45], MI [46], LVH [47] |
| miR-24 | MI [59, 60] | |
| miR-150 | MI [62] | |
| Caspase | ||
| Caspase-1 (NM_001223) | No miRNA meets the screening criteria | |
| Adaptor protein | ||
| ASC/PYCARD (NM_013258) | No miRNA meets the screening criteria | |
*In TargetScan search, only the “miRNA families broadly conserved among vertebrates” for each of the target proteins were used to generate this table. DCM: dilated cardiomyopathy, AS: aortic stenosis, MI: myocardial infarction, and LVH: left ventricular hypertrophy.