Table 3.
Selected examples of miRNAs targeting human negative regulators of pyroptosis and reported to be increased in CVDs.
| Negative regulators of pyroptosis (NCBI Refseq, reference) |
miRNAs predicted by *TargetScan and reported to be upregulated in CVDs | Related CVDs [reference] |
|---|---|---|
| Autophagy | ||
|
ATG16L1 (autophagy-related gene 16 like-1) (NM_017974, [52]) |
Let-7 | DCM, ICM, AS [45] |
| miR-125 | DCM [45, 64], AS [45], LVH [65] | |
| miR-181 | DCM [64], AS [45] | |
| miR-214 | DCM [45, 64], ICM, AS [45], LVH [65] | |
|
MAP1LC3B (microtubule-associated proteins 1A/1B light chain 3B) (NM_022818, [54]) |
miR-30e-5p | DCM, AS [45] |
| miR-145 | AS [45] | |
| miR-214 | DCM, ICM, AS [45], LVH [65, 66] | |
| miR-221 | LVH [65] | |
| miR-222 | DCM, ICM [45], LVH [65] | |
|
BECN1 (Beclin1) (NM_003766, [54]) |
miR-30e-5p | DCM, AS [45] |
| miR-199 | DCM, ICM [45], LVH [65, 66] | |
| Transcription factors | ||
| STAT1 (NM_007315, [56]) | miR-140 | DCM, ICM, AS [45], LVH [65] |
| miR-21 | LVH [65, 66] | |
| miR-23 | DCM, ICM, AS [45], LVH [65, 66] | |
| miR-24 | ICM, AS [45] | |
| FOXO3 | miR-27 | LVH [65, 66] |
| (NM_001455) | miR-30d | Diabetic cardiomyopathy [57] |
| * experimentally proven to | miR-99 | DCM, AS [45] |
| be regulated by miR-30d [57] | miR-103 | DCM, ICM, AS [45], LVH [65] |
| miR-125 | DCM, AS [45], LVH [65, 66] | |
| miR-217 | LVH [66] | |
| miR-221/222 | LVH [65] | |
| NO synthase | ||
| NOS2 (inducible nitric oxide synthase) |
miR-15 | DCM, AS [45] |
| (NM_000625, [67]) | miR-214 | DCM [64], LVH [65, 66] |
*In TargetScan search, only the “miRNA families broadly conserved among vertebrates” for each of the target proteins were used to generate this table. DCM: dilated cardiomyopathy, AS: aortic stenosis, MI: myocardial infarction, and LVH: left ventricular hypertrophy.