Table 3.
Univariate and multivariate analyses of the prognostic factors in patients with hepatoduodenal lymph node metastasis
| n | 5-yr OS (%) | MST (mo) | Univariate |
Multivariate |
||
| P value | HR (95%CI) | P value | ||||
| 26 | 28.7 | 14.1 | ||||
| Sex | ||||||
| Male | 16 | 27.1 | 12.2 | |||
| Female | 10 | 25.7 | 16.9 | 0.753 | - | |
| Age (yr) | ||||||
| < 65 | 10 | 38.1 | 14.1 | |||
| ≥ 65 | 16 | 0 | 12.2 | 0.483 | - | |
| CA 19-9 (U/mL) | ||||||
| < 10 | 17 | 35.7 | 16.9 | |||
| ≥ 10 | 9 | 0 | 12.2 | 0.327 | - | |
| CEA (ng/mL) | ||||||
| < 3 | 16 | 35.8 | 14.1 | |||
| ≥ 3 | 10 | 0 | 9.1 | 0.382 | - | |
| Tumor location | ||||||
| U | 2 | 0 | 8.7 | |||
| M and L | 24 | 30.0 | 14.1 | 0.569 | - | |
| Histopathological type | ||||||
| Differentiated | 10 | 0 | 16.9 | |||
| Undifferentiated | 16 | 40.9 | 14.1 | 0.529 | - | |
| Venous invasion | ||||||
| (-) | 12 | 0 | 14.1 | |||
| (+) | 14 | 16.7 | 16.9 | 0.411 | - | |
| Lymphatic invasion | ||||||
| (-) | 3 | 0 | 9.1 | |||
| (+) | 23 | 26.9 | 14.1 | 0.624 | - | |
| Tumor size (mm) | ||||||
| < 45 | 5 | 0 | 9.1 | |||
| ≥ 45 | 21 | 31.4 | 14.1 | 0.274 | - | |
| T-category | ||||||
| T1 and T2 | 3 | 0 | 9.1 | |||
| T3 and T4 | 23 | 31.5 | 16.9 | 0.222 | - | |
| N-category | ||||||
| N1 or N2 | 10 | 62.5 | 16.8 | |||
| N3 | 16 | 0 | 8.8 | 0.002 | 5.17 (1.8-292.7) | 0.021 |
OS: Overall survival; MST: Median survival time; CEA: Carcinoembryonic antigen; CA 19-9: Carbohydrate antigen 19-9; U: Upper gastric body; M: Middle gastric body; L: Lower gastric body.