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. Author manuscript; available in PMC: 2015 Nov 4.
Published in final edited form as: Neurochem Res. 2015 Apr 11;40(10):2102–2112. doi: 10.1007/s11064-015-1560-y

Fig. 1.

Fig. 1

a High throughput screening layout of 1144 plant based polyphenolics, synthetic/control drugs (including celcoxib, ibuprofen, paclitaxel etc.) and aqueous extracts of 947 commonly used herbs and spices for ability to induce neurite outgrowth in PC-12 cells relative to NGF on collagen coated plates over 7 days. Of the initial screened, with subsequent validation using a full dose range, only one positive NGF mimetic was elucidated. b Morphological analysis of neurite outgrowth in PC12 cells at 7 days; controls (top) NGF 0.5 μg/mL (mid) and MCS extract (150 µg/mL) (bottom)