Abstract
One hundred patients with tracheobronchial tumours were treated with the neodymium YAG (yttrium-aluminium-garnet) or argon laser for symptoms of airways obstruction caused by tumour (59 cases), complete collapse of a lung (17 cases), or recurrent haemoptysis (24 cases). Seventy four of them had relapsed or failed to respond to radiotherapy or chemotherapy and all were inoperable. Objective improvement in results of lung function tests or haemoptysis diary charts was seen in 37 patients with airways obstruction (63%), five (29%) with collapsed lung, and 14 (58%) with haemoptysis. Overall, 68 patients had symptomatic benefit and there was objective improvement in 56. Two deaths occurred in 288 treatment sessions both occurring as a result of asphyxia from minor haemorrhage in patients with advanced cylindromas and critical narrowing of the trachea or single remaining bronchus. In suitable patients with intraluminal tumour laser phototherapy is a valuable addition to conventional treatment.
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- Butland R. J., Pang J., Gross E. R., Woodcock A. A., Geddes D. M. Two-, six-, and 12-minute walking tests in respiratory disease. Br Med J (Clin Res Ed) 1982 May 29;284(6329):1607–1608. doi: 10.1136/bmj.284.6329.1607. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cortese D. A., Kinsey J. H. Endoscopic management of lung cancer with hematoporphyrin derivative phototherapy. Mayo Clin Proc. 1982 Sep;57(9):543–547. [PubMed] [Google Scholar]
- Dumon J. F., Reboud E., Garbe L., Aucomte F., Meric B. Treatment of tracheobronchial lesions by laser photoresection. Chest. 1982 Mar;81(3):278–284. doi: 10.1378/chest.81.3.278. [DOI] [PubMed] [Google Scholar]
- Forbes I. J., Cowled P. A., Leong A. S., Ward A. D., Black R. B., Blake A. J., Jacka F. J. Phototherapy of human tumours using haematoporphyrin derivative. Med J Aust. 1980 Nov 1;2(9):489–493. doi: 10.5694/j.1326-5377.1980.tb100708.x. [DOI] [PubMed] [Google Scholar]
- Gardner W. N., Hugh-Jones P., Carroll M. A., Hewitt E. R., Hewitt H. B., Whimster W. Quantitative analysis of effect of neodymium-YAG laser on transplanted mouse carcinomas. Thorax. 1982 Aug;37(8):594–597. doi: 10.1136/thx.37.8.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hayata Y., Kato H., Konaka C., Ono J., Takizawa N. Hematoporphyrin derivative and laser photoradiation in the treatment of lung cancer. Chest. 1982 Mar;81(3):269–277. doi: 10.1378/chest.81.3.269. [DOI] [PubMed] [Google Scholar]
- Hetzel M. R., Millard F. J., Ayesh R., Bridges C. E., Nanson E. M., Swain C. P., Williams I. P. Laser treatment for carcinoma of the bronchus. Br Med J (Clin Res Ed) 1983 Jan 1;286(6358):12–16. doi: 10.1136/bmj.286.6358.12. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Häussinger K., Held E., Huber R. Endobronchial laser therapy--differential therapeutic use and clinical value. Klin Wochenschr. 1984 Jan 16;62(2):74–80. doi: 10.1007/BF01769666. [DOI] [PubMed] [Google Scholar]
- Toty L., Personne C., Colchen A., Vourc'h G. Bronchoscopic management of tracheal lesions using the neodynium yttrium aluminium garnet laser. Thorax. 1981 Mar;36(3):175–178. doi: 10.1136/thx.36.3.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vincent R. G., Dougherty T. J., Rao U., Boyle D. G., Potter W. R. Photoradiation therapy in advanced carcinoma of the trachea and bronchus. Chest. 1984 Jan;85(1):29–33. doi: 10.1378/chest.85.1.29. [DOI] [PubMed] [Google Scholar]
- Weishaupt K. R., Gomer C. J., Dougherty T. J. Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. Cancer Res. 1976 Jul;36(7 Pt 1):2326–2329. [PubMed] [Google Scholar]