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. Author manuscript; available in PMC: 2016 Oct 13.
Published in final edited form as: Vaccine. 2015 Jul 17;33(42):5715–5722. doi: 10.1016/j.vaccine.2015.07.010

Fig. 2. Changes in Mtb cellular and humoral immune responses in rhesus macaques after immunization with wild-type BCG, rBCG, or rDNA.

Fig. 2

Rhesus macaques were immunized with either wild type (WT) BCG (open triangles, n=5), rBCG expressing SIV Gag (open squares, n=20), or rDNA expressing SIV Gag, Pol, and Nef (closed circles, n=5). (A) Cellular responses to Mtb PPD at baseline, and at 4 and 8 weeks after immunization. (B-C) Correlation between Mtb cellular responses at baseline and 4 and 8 weeks post immunization for the rhesus macaques given either WT BCG or rBCG (n=25). (D) Humoral responses to Mtb WCL in the same groups. (E-F) Correlation between Mtb humoral responses at baseline and 4 and 8 weeks post immunization for the same groups. Bars in panels A and D represent medians. Zero values for ELISpot are plotted on the axis. Comparisons between two groups by Mann Whitney Rank Sum Test. **P<0.01, ***P<0.001.