Fig. 1.

Domain structures of zIQGAPs. Schematic of the three IQGAP proteins of Danio rerio displaying positions of the different conserved domains: CHD (calponin homology domain –mediates actin-binding and binds calponin); IQ repeats (repeated coiled-coil domains), WW (double tryptophan-containing protein-protein interaction domain that associates with proline-rich regions of other proteins), IQ motifs (calmodulin-binding), GRD (GAP-related domain - similar to the catalytic regions of Ras GTPase-activating proteins) and RasGAP C (RasGAP C-terminus-like domain important for binding β-catenin and E-cadherin).