Table 2. Gene ontology term enrichment of circular RNA generating genes.

Category (enrichment score)	Description	Count	Fold enrichment	False discovery rate
Nucleotide and adenosine-triphosphate binding (6.60)	Purine nucleotide binding	87	1.78	7.79E-05
	Purine ribonucleotide binding	84	1.80	8.05E-05
	Ribonucleotide binding	84	1.80	8.51E-05
	Nucleoside binding	77	1.86	9.54E-05
	Purine nucleoside binding	76	1.85	1.46E-04
	Nucleotide binding	98	1.68	1.53E-04
	Adenyl ribonucleotide binding	72	1.89	1.55E-04
	Adenyl nucleotide binding	75	1.86	1.56E-04
	ATP binding	71	1.91	1.57E-04
Nuclear lumen (4.88)	Nucleoplasm	40	2.23	4.18E-03
	Membrane-enclosed lumen	59	1.82	7.17E-03
	Nuclear lumen	47	1.97	1.38E-02
	Intracellular organelle lumen	55	1.81	2.08E-02
	Organelle lumen	56	1.78	2.82E-02
	Nucleoplasm part	26	2.34	1.62E-01
GTPase regulator activity (3.63)	Small GTPase regulator activity	19	3.53	1.05E-02
	Regulation of small GTPase mediated signal transduction	19	3.37	2.35E-02
	GTPase regulator activity	22	2.76	7.08E-02
	Nucleoside-triphosphatase regulator activity	22	2.70	9.83E-02
	Regulation of Ras protein signal transduction	15	3.38	2.39E-01
	Enzyme activator activity	16	2.86	7.12E-01
	GTPase activator activity	12	3.37	1.24E+00
	Regulation of GTPase activity	9	3.83	3.93E+00
	Regulation of Ras GTPase activity	8	4.26	4.38E+00
Ion binding (3.53)	Zinc ion binding	71	1.63	4.83E-02
	Transition metal ion binding	84	1.50	1.36E-01
	Metal ion binding	116	1.36	2.46E-01
	Cation binding	116	1.34	4.35E-01
	Ion binding	116	1.32	8.71E-01
Protein kinase activity (3.49)	Phosphate metabolic process	54	2.17	1.92E-04
	Phosphorus metabolic process	54	2.16	2.04E-04
	Phosphorylation	46	2.19	1.54E-03
	Protein amino acid phosphorylation	41	2.26	3.32E-03
	Protein kinase activity	38	2.26	7.63E-03
	Protein serine/threonine kinase activity	30	2.55	9.75E-03

ATP=adenosine triphosphatase; GTPase=guanosine triphosphatase.