Table 2.
Plasma NGAL levels and NGAL/sCr ratios in relation to kidney function in patients with inflammation.
| Patients with inflammation | P value | ||
|---|---|---|---|
| Without renal impairment (sCr < 1.2 mg/dL, n = 93) |
With renal impairment (sCr ≥ 1.2 mg/dL, n = 69) |
||
| Lipocalin levels | |||
| NGAL (ng/mL) | 125.0 (76.0–208.0) | 417.0 (182.5–973.5) | <0.001 |
| NGAL/sCr ratio | 121.0 (71.7–204.9) | 229.9 (100.2–320.3) | <0.001 |
| Percent difference (95% CI) | 0.0 (0.0–14.1) | 36.7 (18.4–83.7) | <0.001 |
| NGAL > 150 ng/mL (n, %) | 37 (39.8) | 55 (79.7) | <0.001 |
| Inflammation indices | |||
| hsCRP (mg/dL) | 3.24 (0.98–8.41) | 6.17 (3.21–14.76) | <0.001 |
| cESR (mm/h) | 20.9 (9.7–36.5) | 32.8 (15.2–54.2) | 0.004 |
| Neutrophil (×109/L) | 6.17 (4.23–10.06) | 7.05 (4.92–11.37) | 0.095 |
| NLR | 3.8 (2.9–10.2) | 5.7 (3.1–12.7) | 0.037 |
| Kidney function | |||
| eGFR (mL/min/1.73 m2) | 82.4 (72.4–101.4) | 42.3 (23.3–53.7) | <0.001 |
| sCr (mg/dL) | 0.83 (0.74–1.03) | 1.58 (1.31–2.55) | <0.001 |
| BUN (mg/dL) | 13.7 (10.9–19.4) | 30.8 (20.5–49.7) | <0.001 |
Data are expressed as median (interquartile range) or frequency (%).
NGAL, neutrophil gelatinase-associated lipocalin; NGAL/sCr ratio, NGAL-to-serum creatinine ratio; hsCRP, high sensitivity C-reactive protein; cESR, corrected erythrocyte sedimentation rate; NLR, neutrophil-to-lymphocyte ratio; eGFR, estimated glomerular filtration rate; sCr, serum creatinine; BUN, blood urea nitrogen.