Table 7.
Prior specification for organ volumes and flows of an adult male population as used in Allen et al. (2007).
| Parameter | Distribution | Bounding Interval |
|---|---|---|
| Body Weight (BW) (kg) | LN(log(67.77), log(1.603)) | (30.81, 139.9) |
| Cardiac Output (L/hr) | N(20, 10) | (6.8, 33.2) |
| TISSUE VOLUME (AS FRACTION OF BW) | ||
| Liver volume | N(0.026, 0.013) | (0.006, 0.046) |
| Kidney volume | N(0.004, 0.002) | (0.0004, 0.008) |
| Brain volume | N(0.02, 0.01) | (0.002, 0.038) |
| Intestine volume | N(0.014, 0.007) | (0.001, 0.027) |
| Gut volume | N(0.017, 0.0085) | (0.009, 0.025) |
| Richly perfused tissue volume | N(0.10, 0.05) | (0.01, 0.190) |
| Slowly perfused tissue volume | N(0.35, 0.175) | (0.18, 0.52) |
| Adipose volume | N(0.273, 0.14) | (0.076, 0.47) |
| Remainder (non-perfused) | N(0.122, 0.061) | (0.012,0.23) |
| PLASMA FLOW (AS FRACTION OF CARDIAC OUTPUT) | ||
| Liver flow | N(0.046, 0.023) | (0.01, 0.090) |
| Kidney flow | N(0.175, 0.0875) | (0.018,0.333) |
| Brain flow | N(0.114, 0.057) | (0.011, 0.217) |
| Gut flow | N(0.181, 0.0905) | (0.002, 0.360) |
| Richly perfused tissue flow | N(0.183, 0.0915) | (0.018, 0.348) |
| Slowly perfused tissue flow | N(0.249, 0.1245) | (0.025, 0.473) |
| Adipose flow | N(0.052, 0.0256) | (0.0052, 0.099) |
Upper and lower bounds taken from Clewell et al. (1999).