Figure 1.

HDAC structure and expression in adult human bone and cartilage. A: HDACs are grouped into four classes based on structural considerations. B–E: HDAC gene expression differs between bone and cartilage as illustrated by RNA-sequencing results (van Wijnen, unpublished data). RNA samples were obtained with Institutional Review Board approval from adult human bone (4 specimens) and articular cartilage (3 specimens) as fresh surgical waste. Each colored bar represents a different patient. Values represents reads per kilobase per million (RPKM).