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. 2015 Oct 12;6:500. doi: 10.3389/fimmu.2015.00500

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Copyright © 2015 Bougherara, Mansuet-Lupo, Alifano, Ngô, Damotte, Le Frère-Belda, Donnadieu and Peranzoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Back and forth migration of resident CD8 T cells in the stroma of human ovarian carcinomas. (A) Representative image of a resident CD8 T cell that exhibits a back and forth migration mode relative to collagen fibers. See also Movie S13 in Supplementary Material. Left: SHG signal (red) alone. Dotted lines indicate the spacing between collagen fibers. Right: same SHG image as in left but with a CD8 T cell (green) and its trajectory (white line) during a 17-min recording. (B) Spacing between collagen fibers are shown for CD8 T cells that display either back and forth or random migration. The durations of the tracks were non-significantly different within the two groups (13.5 ± 2.6 min for CD8 T cells that exhibit back and forth migration vs. 16.8 ± 2.6 min for CD8 T cells that migrate randomly). Values are compiled from four different ovarian tumors. t-test, *P < 0.05; **P < 0.01; ***P < 0.001.