Table 3. Unadjusted univariate analysis of muscle gene expression of immune and inflammatory markers correlated with different fat depots.
Marker | %FM |
IMCL |
VAT |
Intrahepatocellular fat |
||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
β | SE β | P-value | β | SE β | P-value | β | SE β | P-value | β | SE β | P-value | |
Cytokines | ||||||||||||
TNFα | −0.014 | 0.006 | 0.02 | 0.073 | 0.139 | 0.60 | 0.001 | 0.001 | 0.92 | 0.000 | 0.009 | 1.00 |
IL-6 | 0.000 | 0.008 | 0.98 | 0.117 | 0.185 | 0.53 | 0.001 | 0.001 | 0.25 | 0.017 | 0.011 | 0.14 |
IL-10 | 0.003 | 0.012 | 0.83 | 0.061 | 0.256 | 0.81 | 0.001 | 0.001 | 0.64 | 0.014 | 0.016 | 0.39 |
Chemokine/receptor | ||||||||||||
CCL2 | 0.017 | 0.007 | 0.02 | 0.209 | 0.166 | 0.21 | 0.000 | 0.001 | 0.69 | 0.010 | 0.010 | 0.34 |
CCL3 | −0.019 | 0.010 | 0.08 | 0.349 | 0.228 | 0.13 | 0.001 | 0.001 | 0.50 | 0.006 | 0.014 | 0.66 |
IL-8 | 0.018 | 0.010 | 0.09 | 0.311 | 0.225 | 0.17 | 0.001 | 0.001 | 0.67 | 0.001 | 0.014 | 0.97 |
CCR2 | 0.015 | 0.007 | 0.04 | 0.069 | 0.155 | 0.66 | 0.000 | 0.001 | 0.76 | 0.001 | 0.010 | 0.95 |
TLRs | ||||||||||||
TLR2 | 0.004 | 0.008 | 0.57 | 0.213 | 0.171 | 0.22 | 0.000 | 0.001 | 0.89 | 0.001 | 0.011 | 0.96 |
TLR4 | −0.017 | 0.009 | 0.07 | 0.099 | 0.205 | 0.63 | 0.000 | 0.001 | 0.83 | 0.004 | 0.013 | 0.73 |
Inflammasome | ||||||||||||
IL-1β | −0.007 | 0.010 | 0.48 | 0.170 | 0.212 | 0.43 | 0.001 | 0.001 | 0.25 | 0.015 | 0.013 | 0.24 |
IL-18 | −0.009 | 0.012 | 0.45 | 0.076 | 0.264 | 0.78 | 0.002 | 0.001 | 0.13 | 0.004 | 0.016 | 0.82 |
NLRP3 | −0.023 | 0.010 | 0.02 | 0.279 | 0.225 | 0.22 | 0.001 | 0.001 | 0.34 | 0.018 | 0.014 | 0.19 |
Immune cells | ||||||||||||
CD68 | −0.020 | 0.010 | 0.05 | 0.217 | 0.224 | 0.34 | 0.001 | 0.001 | 0.55 | 0.009 | 0.014 | 0.50 |
MRC1 | −0.010 | 0.008 | 0.23 | 0.223 | 0.185 | 0.23 | 0.003 | 0.001 | 0.01 | 0.007 | 0.012 | 0.55 |
CD11c | −0.011 | 0.007 | 0.13 | 0.258 | 0.159 | 0.11 | 0.000 | 0.001 | 0.65 | 0.007 | 0.010 | 0.52 |
MPO | 0.065 | 0.017 | 0.0003 | 0.017 | 0.424 | 0.97 | 0.004 | 0.002 | 0.08 | 0.044 | 0.025 | 0.09 |