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Comparison of K101 (orange) interactions for RT (WT) in complex with (A) efavirenz (PDB code: 1FK9), (B) rilpivirine (PDB code: 2ZD1), and (C) compound 3 (PDB code: 4MFB). Compound 3 binds farther away from the E138-K101 salt bridge and does not interact with K101.
