Figure 2. Metabolic profiles of older GPR3 mice as analyzed by means of indirect calorimetry.

The O₂ consumption and CO₂ production were monitored by indirect calorimetry in older (12-month-old) male GPR3 wild type (WT) and knockout (KO) mice and presented as average of a 24-hour recording period (left panels) or as hourly observations (right panels; shaded area indicates lights off). Shown are total energy expenditure (TEE; (A)), respiratory quotient (RQ; (B)), food intake (C) and ambulatory activity (D). Values are mean ± s.e.m of n = 5–8 samples *P < 0.05, ***P < 0.001 compared to age-matched WT littermates.