Figure 3. GPR3 KO mice display late onset obese phenotype with unchanged metabolic profile until adulthood.

(A) Body weight monitoring for 18 months in male GPR3 wild type (WT) and knock out (KO) mice. Values are mean ± s.e.m of n = 7–23 animals. *P < 0.05, **P < 0.01, ***P < 0.001 compared to the age-matched WT littermates. (B–E) Results of the monitoring of O₂ consumption and CO₂ production by indirect calorimetry in adult (5-month-old) male GPR3 wild type (WT) and knockout (KO) mice. Data are presented as average of a 24-hour recording period. Shown are: total energy expenditure (TEE; (B)), respiratory quotient (RQ; (C)), food intake (D) and ambulatory activity (E). Values are mean ± s.e.m of n = 6–8 samples.