Figure 4.

Cldn11-null myelin undergoes more rapid osmotic compaction and recovery. (A) Myelin period was measured in optic nerves from control (+/±) and Cldn11-null (−/−) mice while nerves were perfused with hyperosmotic sucrose. Points and error bars represent the average myelin period measured from n = 3 mice in each group at each time point ±1 standard deviation. For clarity, the inset shows an enlarged view of the first 15 min of the experiment. (B) Relaxation times τ were extracted from single-exponential decay models fit to plots of period versus time during osmotic compaction and recovery. Average relaxation times for each group are shown ±1 standard deviation. Statistical significance was calculated using a t-test between average relaxation times measured from control (+/±; n = 3) and Cldn11-null (−/−; n = 3) mice. To see this figure in color, go online.