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. Author manuscript; available in PMC: 2015 Oct 12.
Published in final edited form as: Nature. 2007 Jan 24;445(7128):656–660. doi: 10.1038/nature05529

Figure 2. The primary response to p53 reactivation is not apoptosis.

Figure 2

a, Haematoxylin and eosin (H&E) immunohistochemical staining for apoptotic cells (TUNEL and Caspase 3 staining) and proliferating cells (Ki67 staining) of liver tumours before (p53 off) and after Dox treatment (p53 on). Tumours showed histopathology of human hepatocellular and cholangiocellular carcinoma. Inset (P) denotes positive controls (irradiated thymus, 20Gy (20 Gray)). ‘p53 on’ shows representative tumour on day 6. Scale bar, 100 μm. b, Quantification of a. Values represent mean ± s.d. (n = 4; **P<0.002).