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. Author manuscript; available in PMC: 2015 Oct 12.
Published in final edited form as: J Am Chem Soc. 2013 Feb 4;135(6):2088–2091. doi: 10.1021/ja311961k

Figure 1.

Figure 1

For the covalent delivery of unmodified probes, guanidinium-containing propagators (e.g., 1–4) are polymerized on thiolated substrates (e.g., 5–7) and terminated with iodoacetamides (e.g., 8, 9). After uptake, cell-penetrating poly(disulfide)s are degraded by reductive depolymerization to eliminate toxicity and release the unmodified substrate.