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A schematic model illustrating PrPC effects on self-renewal and differentiation of hESCs into neural lineages. Expression of PrPC in pluripotent hESCs triggers their differentiation into neuron-, oligodendrocyte- and astrocyte-committed lineages. PrPC guides differentiation at the very early stage, presumably the stage of uncommitted progenitor, via a yet unknown signaling pathway or through inhibiting cell-renewal.
