Figure 1.

Antifungal drug targets and related drug resistant mechanisms of C. albicans Antifungal drugs and their targets: (A) polyenes, target is ergosterol; (B) azoles, target is ergosterol biosynthesis; (C) echinocandins, target is β(1 3)-D-glucan synthesis; (D) fluoropyrimidine, target is nucleic acids synthesis; (E) sordarins, target is protein synthesis; (F) griseofulvin, target is mitosis; (G) and arylamidines, target is mitochondria. The general drug resistant mechanisms in C. albicans include: 1. target overexpression; 2. targets alteration; 3. drug sequestration; 4. enhanced drug efflux; and 5. blocking of antifungal drug entry.