Table 1.

^*Selected synergistic combinations against C. albicans in vitro and in vivo.

Data from	Wild type or resistance#	Synergistic combination	Reference
In vitro Animal	Wild type and Resistance	Beauvericin + Clotrimazole, or Fluconazole, or Itraconazole, or Ketoconazole, or Miconazole	Unpublished
In vitro	Wild type and Resistance	Rapamycin + peptides	Unpublished
In vitro	Wild type and Resistance	Ketoconazole + Avilamycin	Unpublished
In vitro	Wild type and Resistance	Ketoconazole + Spinosad	Unpublished
In vitro	Wild type and Resistance	Nitroimidazoles + Amphotericin B	83
In vitro	Wild type and Resistance	Histatin 5 and its analogs Amphotericin B	84
In vitro	Wild type and Resistance	Tetrandrine + Ketoconazole	85
In vitro	Wild type and Resistance	Fluconazole + Thymol, or Carvacrol	86
In vitro	Wild type and Resistance	Geldanamycin + Fluconazole	87
In vitro	Wild type and Resistance	Pure polyphenol curcumin I + Fluconazole, or Miconazole, or Ketoconazole, or Itraconazole, or Voriconazole, or Nystatin or Amphotericin B	88
In vitro	Wild type and Resistance	Berberine + Fluconazole	89-91
In vitro	Wild type and Resistance	Fluconazole + alverine citrate, or Caspofungin, Latrunculin-A, or Wortmannin, or Fenpropimorph	92
In vitro	Wild type and Resistance	Tunicamycin + FK506, or Cyclosporine-A	92
In vitro	Wild type and Resistance	Wortmannin + Tunicamycin, or FK506	92
In vitro	Wild type and Resistance	Posaconazole + Caspofungin, or FK506	93
In vitro	Wild type and resistance	Amphotericin B + Terbinafine	94
In vitro	Wild type and Resistance	Flucytosine + Econazole, or Miconazole	95
In vitro	Wild type and Resistance	Fluvastatin + Fluconazole, or Itraconazole	96
In vitro	Wild type and Resistance	FK506 + Fluconazole, or Voriconazole, or Itraconazole	97
In vitro	Wild type and Resistance	Retigeric acid B + Fluconazole, or Ketoconazole, or Itraconazole	98
In vitro	Wild type and Resistance	Lactoferrin + Fluconazole, or Itraconazole	99
In vitro	Wild type and Resistance	Farnesol + Fluconazole, or Ketoconazole, or Miconazole, or Amphotericin B	100
In vitro	Wild type and Resistance	Amiodarone + Fluconazole, or Voriconazole, or Itraconazole	101
In vitro	Resistance	Eugenol + Amphotericin B, or Fluconazole	102
In vitro	Resistance	Honokiol + Fluconazole	103
In vitro	Resistance	Glabridin + Fluconazole	104
In vitro	Resistance	Tioconazole + Butylated hydroxyanisole	105
In vitro	Resistance	Baicalein + Amphotericin B	106
In vitro	Resistance	Curcumin+ R6G, or Ketoconazole, or Itraconazole, or Miconazole	107
In vitro	Resistance	Anidulafungin + Posaconazole, or Amphotericin B	108
In vitro	Resistance	Caspofungin + Posaconazole, or Micafungin	108
In vitro	Resistance	Minocycline + Fluconazole	109
In vitro	Resistance	Baicalein + Fluconazole	110
In vitro	Resistance	Ofloxacin + Fluconazole	111
In vitro	Biofilm and Planktonic cells	Fluconazole + FK506, or Cyclosporine A	112
In vitro	Biofilm and Planktonic cells	Berberine + Miconazole	113
In vitro	Biofilm and Planktonic cells	Aspirin + Amphotericin B	114
In vitro	Biofilm	Tyrocidines + Amphotericin B, or Caspofungin	115
In vitro	Biofilm	Amphotericin B + Drospirenone, or Perhexiline, or Toremifene	116
In vitro	Biofilm	Caspofungin + Drospirenone, or Perhexiline, or Toremifene	116
In vitro	Biofilm	Amphotericin B + N-acetylcysteine, or EDTA, or Ethanol, or Talactoferrin	117
In vitro	Biofilm	Fluconazole + N-acetylcysteine, or EDTA, or Ethanol, or Talactoferrin	117
In vitro	Biofilm	Terpenes + Fluconazole	118
In vitro	Biofilm	Doxycycline + Fluconazole	119
In vitro	Biofilm	Silver nanoparticles + nystatin, or chlorhexidine digluconate	120
In vitro	Biofilm	Doxycycline + Fluconazole	121
In vitro	Biofilm	Shearinines D (3) and E (4) + Amphotericin B	122
In vitro	Biofilm	Verapamil + Fluconazole, or Tunicamycin	123
In vitro	Biofilm	Cyclosporine A + Fluconazole, or Voriconazole, or Amphotericin B, or Caspofungin	124
In vitro	Biofilm	Amphotericin B + Rifampicin, or Clarithromycin	125
Animal	Wild type and resistance	Posaconazole + Caspofungin, or FK506	126
Animal	Resistance	Amphotericin B + Caspofungin	127
Animal	Resistance	Tetrandrine + Ketoconazole	128
Animal	Wild type	Berberine + Amphotericin B	129
Animal	Wild type	Cilofungin + Amphotericin B	130
Animal	Wild type	Antimicrobial peptides + Caspofungin	131
Animal	Wild type	Nikkomycin Z + R 3783	132
Animal	Wild type	Amphotericin B + Ketoconazole, or 5-Fluorocytosine	133
Animal	Wild type	5-Fluorocytosine + Fluconazole, or Itraconazole	133
Animal	Biofilm	Fluconazole + FK506, or Cyclosporine A	112
Clinic trials	Clinical	Amphotericin B + 5-Fluorocytosine	134-137
Clinic trials	Clinical	5-Fluorocytosine + Azoles	138
Clinic trials	Clinical	Amphotericin B + Azoles	139
Clinic trials	Clinical	Terbinafine + Itraconazole or Fluconazole	140
Clinic trials	Clinical	Mycograb + lipid-associated amphotericin B	141

^*Because strains, culture conditions, susceptibility testing methods and models used to define synergy in these studies were different, results from different literatures may be contrary to each other, only synergy reports were selected in this table.

^#Strains were labeled as wild type if they were not claimed as resistance explicitly in the reference. For clinical trials, the infection sources are not distinguished, all labeled as clinical.