Figure 2.
Disruption of PrPC-HOP/STI1 interaction using anti-HOP antibodies in xenografts increases the survival of animals with glioblastoma. Preliminary results indicate that disruption of the PrPC-HOP/STI1 complex using a specific antibody increases animal survival. Briefly, nude mice were injected orthotopically with a U87 cell line (5×105 cells) and treated with HOP/STI1-antibody25 for 28 d (240 ng/day) using osmotic micropumps. The complete methodology is described in Lopes et al.28 Kaplan–Meier survival curve of mice implanted with U87 cells. Log-rank p = 0.0023, n = 3 mice per group.