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. 2014 Dec 3;5(2):e973768. doi: 10.4161/21541248.2014.973768

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 2. — Apical exclusion of Baz/Par3 defines the apical-lateral border. Cdc42-mediated signaling through Par6-aPKC and Crumbs excludes Baz/Par3 from the apical domain and thereby defines the apical-lateral border.^46,47,49. This process involves 2 mechanisms: 1. aPKC-mediated phosphorylation of Baz at Serine 980 to disrupt the Baz-aPKC interaction, and 2. Crumbs-mediated inhibition of the Baz-Par6 interaction. P = phosphorylation.