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. 2014 Dec 3;5(2):e973768. doi: 10.4161/21541248.2014.973768

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — Epithelial cell-cell junctions are regulated by multiple signaling pathways that include the Rho family GTPases. (A) Shown are the main constituents of epithelial adherens junctions (AJs) and tight junctions (TJs) that connect to numerous cytoplasmic signaling and scaffolding molecules in a cytoplasmic plaque, which subsequently link the junctions with the Rho family GTPases. (B and C) Shown are the numerous molecular mechanisms involving the Rho GTPases that control epithelial AJs (B), and TJs (C). Dotted line represents a speculated link.