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Schematic representation of epithelial cell polarity plasticity. Many aspects of an epithelial cells’ polarity machinery are multi-functional, potentially permitting a switch from promoting apicobasal polarity to front-rear polarity, which promotes directed cell migration. Shown are some of the Rho GTPase signaling complexes that have been implicated in the regulation of both types of polarization, and are therefore possible candidates for mediating such a polarity switch.
