D-dimer, TAT and clotting time analysis. D-dimer analysis of plasma from untreated mice or mice treated with PA (4.4 mg/kg), LT (4.4 mg/kg), and LPS (5 ng/kg) for 0, 6, 24 and 72 h, respectively (A). TAT analysis of plasma from untreated, PA, LT, and LPS treated mice (72 h) (B). Recalcification plasma clotting time analysis of plasma samples collected from untreated, PA, LT, and LPS treated mice (72 h) (C), or normal mice plasma treated with or without PA, LT or anti-PA Ig preincubated LT (LT + anti-PA) (2 h in vitro) (D). Activated partial thromboplastin time (APTT) and prothrombin time (PT) analysis of plasma from untreated, PA, and LT treated mice (E). *P < 0.05, **P < 0.01, compared to respective PA groups. n = 6 (A–E).