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. 2014 Oct 30;13(16):2572–2586. doi: 10.4161/15384101.2015.942209

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Hiroyoshi Hattori, Rekin's Janky, Wilfried Nietfeld, Stein Aerts, M Madan Babu, and Ashok R Venkitaraman

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 3. — miRNA expression during the DDR in MCF10A and HCT116 cells over time. The MA plots in the panels plot for each miRNA species the values of the log fold change (M) against the average abundance (A). We chose as significant those changes in which M ≥ or ≤0.75 (horizontal dotted lines), and A ≥ 5 (vertical dotted lines), i.e., ≥1.68-fold increase or decrease in differential expression (M) and a count rate of ≥32 (A). The MA plot analysis shows 4 comparisons: A, MCF10A 4 h vs 0 h; B, MCF10A 24 h vs 0 h; C, HCT116 4 h vs 0 h; D, HCT116 24 h vs 0 h. miRNAs exhibiting a statistically significant change are color ed in red (p-value < = 0.05).