Table 2.
Effects of Flow Rate on Total Emitted Doses of Budesonide and Formoterol Delivered by Low-, Middle-, and High-Strength Spiromax
| Budesonide | ||||
|---|---|---|---|---|
| Batch number | Flow rate (L/min) | Lowa | Middleb | Highc |
| 1 | 40 | 95 (7) | 92 (11) | 90 (8) |
| 1 | 60 | 102 (7) | 97 (7) | 98 (6) |
| 1 | 90 | 108 (4) | 110 (6) | 101 (6) |
| 2 | 40 | 98 (10) | 99 (8) | 95 (7) |
| 2 | 60 | 105 (7) | 99 (8) | 100 (8) |
| 2 | 90 | 109 (6) | 107 (4) | 101 (6) |
| 3 | 40 | 94 (7) | 93 (10) | 95 (8) |
| 3 | 60 | 100 (6) | 103 (7) | 100 (6) |
| 3 | 90 | 105 (4) | 108 (5) | 103 (5) |
| Formoterol | ||||
|---|---|---|---|---|
| Batch number | Flow rate (L/min) | Lowa | Middleb | Highc |
| 1 | 40 | 89 (7) | 91 (14) | 91 (8) |
| 1 | 60 | 93 (7) | 98 (8) | 100 (8) |
| 1 | 90 | 102 (5) | 113 (8) | 104 (9) |
| 2 | 40 | 89 (8) | 96 (8) | 98 (7) |
| 2 | 60 | 96 (7) | 98 (8) | 103 (10) |
| 2 | 90 | 104 (7) | 109 (6) | 107 (7) |
| 3 | 40 | 84 (7) | 91 (12) | 100 (9) |
| 3 | 60 | 93 (6) | 102 (10) | 104 (6) |
| 3 | 90 | 100 (5) | 113 (7) | 110 (6) |
Values are mean percent relative to label claim and relative standard deviation (%).
a
80/4.5 μg per dose; b160/4.5 μg per dose; c320/9 μg per dose.