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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Proteomics. 2015 Jun 9;15(17):2983–2998. doi: 10.1002/pmic.201500059

Table 5. Human brain particle proteins exclusive to sCJD.

N ProteinName Gene Name Intensity
1 WASL WASL_HUMAN Wiskott-Aldrich syndrome-like 169,140.4
2 DCTN3 DCTN3_HUMAN dynactin 3 (p22) 157,980.3
3 USO1 USO1_HUMAN USO1 homolog, vesicle docking protein (yeast) 126,390.3
4 NDUS7 NDUS7_HUMAN NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH- Q 88,332.1
5 FKBP4 FKBP4_HUMAN FK506 binding protein 4, 59kDa 78,704.9
6 COX7R COX7R_HUMAN cytochrome c oxidase subunit VIIa polypeptide 2 like 57,524.1
7 HD HD_HUMAN huntingtin 49,592.2
8 PPCE PPCE_HUMAN prolyl endopeptidase 40,681.6
9 NDUB7 NDUB7_HUMAN NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa 39,724.8
10 CHM2A CHM2A_HUMAN chromatin modifying protein 2A 39,370.7
11 APOO APOO_HUMAN apolipoprotein O 38,975.3
12 TTC7B TTC7B_HUMAN tetratricopeptide repeat domain 7B 37,903.9
13 VP13D VP13D_HUMAN vacuolar protein sorting 13 homolog D (S. cerevisiae) 37,399.7
14 KI21A KI21A_HUMAN kinesin family member 21A 35,181.9
15 KGUA KGUA_HUMAN guanylate kinase 1 31,610.5
16 CNN3 CNN3_HUMAN calponin 3, acidic 28,600.5
17 NDUS4 NDUS4_HUMAN NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coe 27,990.7
18 CLAP2 CLAP2_HUMAN cytoplasmic linker associated protein 2 26,087.2
19 ATD3A ATD3A_HUMAN ATPase family, AAA domain containing 3A 24,858.7
20 PI42C PI42C_HUMAN phosphatidylinositol-5-phosphate 4-kinase, type II, gamma 24,676.1
21 PI42A PI42A_HUMAN phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 24,055.0
22 PCBP2 PCBP2_HUMAN poly(rC) binding protein 2 23,668.3
23 RS30 RS30_HUMAN Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously e 23,633.2
24 RL7 RL7_HUMAN ribosomal protein L7 pseudogene 26; ribosomal protein L7 pseudogene 21,737.1
25 EF1B EF1B_HUMAN eukaryotic translation elongation factor 1 beta 2; eukaryotic translation e 21,735.4
26 GBLP GBLP_HUMAN guanine nucleotide binding protein (G protein), beta polypeptide 2-like 21,492.4
27 ROCK2 ROCK2_HUMAN Rho-associated, coiled-coil containing protein kinase 2 20,987.8
28 RAB18 RAB18_HUMAN RAB18, member RAS oncogene family 20,773.8
29 S6A11 S6A11_HUMAN solute carrier family 6 (neurotransmitter transporter, GABA), member 1 20,112.7
30 GON4L GON4L_HUMAN YY1 associated protein 1; gon-4-like (C. elegans) 19,555.0
31 ITAV ITAV_HUMAN integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51 19,400.2
32 4-Sep SEPT4_HUMAN septin 4 18,835.6
33 TPRGL TPRGL_HUMAN tumor protein p63 regulated 1-like 18,308.7
34 LPPRC LPPRC_HUMAN leucine-rich PPR-motif containing 17,899.0
35 CPLX1 CPLX1_HUMAN complexin 1 17,831.0
36 TMM65 TMM65_HUMAN transmembrane protein 65 17,611.7
37 SYT12 SYT12_HUMAN synaptotagmin XII 17,491.9
38 LIRB2 LIRB2_HUMAN leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITI 17,041.4
39 APOD APOD_HUMAN apolipoprotein D 16,204.0
40 DNJB1 DNJB1_HUMAN DnaJ (Hsp40) homolog, subfamily B, member 1 16,102.7
41 SH3G1 SH3G1_HUMAN SH3-domain GRB2-like 1 15,567.6
42 ECHM ECHM_HUMAN enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 15,557.8
43 DCTN5 DCTN5_HUMAN dynactin 5 (p25) 14,162.7
44 RPN1 RPN1_HUMAN ribophorin I 13,949.7
45 PSMD1 PSMD1_HUMAN proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 13,793.4
46 RB27B RB27B_HUMAN RAB27B, member RAS oncogene family 13,611.1
47 COF2 COF2_HUMAN cofilin 2 (muscle) 13,449.9
48 RBGPR RBGPR_HUMAN RAB3 GTPase activating protein subunit 2 (non-catalytic) 13,246.6
49 LRC47 LRC47_HUMAN leucine rich repeat containing 47 13,222.8