Table 4. Hydrogen-bond net between fixed water molecules that surround the guanidine group of the ligand and the protein.

Water molecule	Distance (A)	Atom
519	3.60	SArg N13
	3.69	SArg N16
	2.63	Ser207 OG
	2.85	Asp255 OD2
	2.85	Asp255 OD1
	3.38	Asp255 OD2
	2.80	Asp256 OD1
	3.56	Tyr204 O
	3.35	Ser207 N
670	3.57	SArg N13
	2.95	Asn144 ND2
	3.38	Asn144 OD1
	3.73	Ser254 OG
	3.27	Asp255 OD1
	3.43	Asp255 OD2
	2.88	Thr268 OG1
	2.91	H2O532
655	2.88	SArg N15
	3.33	SArg N16
	2.86	Asn144 OD1
	2.96	Ala251 O
	3.14	Ala250 O
	3.33	Arg145 NE1
	3.25	Gly253 N
	3.39	H2O591
591	3.39	H2O655
	2.95	SArg N16
	2.78	Asp256 OD2
	2.89	Gly253 N
	2.77	Ala250 O
	3.32	Gly252 N
	3.74	Tyr208 N
627	2.87	SArg N15
	2.81	Ser207 OG
	2.83	Tyr248 O