Table 1.
| NAME OF FACTOR MADE BY BMSC | KNOWN FUNCTION OF FACTOR | REFERENCE TO FACTOR IN BMSC |
|---|---|---|
| TROPHIC | ||
| Angiopoetin | growth/angiogenesis | 1,2 |
| BDNF | growth/differentiation/anti-apoptotic | 3 |
| bFGF (FGF2) | growth/differentiation | 3,4 |
| BMI-1 | regulates self-renewal | 5 |
| EGF | growth/proliferation/differentiation | 1 |
| Erythropoetin | red cell production | 1 |
| GMFB | nerve growth | 6 |
| HGF | mitogenesis, cell motility | 4,7,8 |
| Keratinocyte growth factor (FGF7) | growth | 1 |
| Macrophage inflammatory factor | leukocyte migration/induce pro-inflammatory cytokines | 1 |
| MCP-1 | monocyte migration | 3 |
| PEDF | antiangiogenesis/neurotrophic | 6 |
| TGF-β | growth/proliferation/differentiation | 7,8 |
| VEGF | vasculogenesis, migration | 2,4,5,8 |
| ANTI-APOPTOTIC AGENTS | ||
| CNTF | anti-apoptotoic | 5 |
| IL-6 | anti-apoptotic | 3,9 |
| IGF (IGF-1) | anti-apoptotic/proliferation | 1,4 |
| NGF | growth/anti-apoptotic | 5,6 |
| ATTRACTANTS | ||
| Eotaxin-3 (CCL-26) | recruits eosinophils, basophils | 10 |
| Fractalkine (CX3CL1) | recruits T cells and monocytes | 10 |
| GRO α, β (CXCL-1, CXCL-2) | recruits neutrophils | 10 |
| i-TAC (CXCL-11) | recruits activated T cells | 10 |
| IL-8 (CXCL-8) | recruits neutrophils | 9,10 |
| IP-10 (CXCL-10) | recruits monocytes/macrophages, T cells, NK cells, dendritic cells | 9,10 |
| MCP-1 (CCL2) | recruits monocytes, memory T cells, dendritic cells | 9,10 |
| MCP-3 (CCL7) | recruits monocytes | 10 |
| MIF | macrophage migration inhibition | 6 |
| MIP1 (CCL4) | recruits monocytes, NK cells | 10 |
| MIP3-a (CCL20) | recruits lymphocytes | 10 |
| RANTES (CCL5) | recruits T cells,eosinophils, basophils | 10 |
| SDF-1 (CXCL-12) | lymphocyte migration | 1,10 |
| IMMUNOMODULATORS | ||
| ENA 78 (CXCL-5) | activates neutrophils | 10 |
| Galectins | anti-inflammatory | 11,12 |
| HLA-G5 | immune supression | 13 |
| IDO | inhibits T cell proliferation | 14 |
| IL-1α, β | cytokines; affect function of a variety of immune cells | 9 |
| INF1 β | anti-inflammatory | 9 |
| LL-37 | anti bacterial | 15 |
| PGE-2 | immune supression | 16,17 |
| TNF-α* | pro-inflammatory cytokine | 9 |
| TSG-6 | anti-inflammatory | 18 |
1 [Chen et al., 2008], 2 [Wu et al., 2007], 3 [Crigler et al., 2006], 4 [Kinnaird et al., 2004], 5 [Crisostomo et al., 2008], 6 [Di Nicola et al., 2002], 7 [Rehman et al., 2004], 8 [Munoz et al., 2005], 9 [Tomchuck et al., 2008], 10 [da Silva Meirelles et al., 2008], 11 [Sioud, 2011], 12 [Gieseke et al., 2010], 13 [Selmani et al., 2008], 14 [Meisel et al., 2004], 15 [Krasnodembskaya et al., 2010], 16 [Aggarwal and Pittenger, 2005], 17 [Nemeth et al., 2009],18 [Lee et al., 2009]