Table 3.
Inhalation Profile Parameters With Handling Configurations 1 or 2 (the Respimat SMI Without or With Parent/Caregiver Assistance in Children Aged ≥3 Years)
| Age group (years) | ||||||||
|---|---|---|---|---|---|---|---|---|
| 3 to <4 | 4 to <5 | |||||||
| n | Median | Min | Max | n | Median | Min | Max | |
| Deltaa (sec) | 6 | −0.210 | −0.452 | 0.308 | 19 | −0.299 | −1.023 | 0.790 |
| Tinb (sec) | 6 | 1.162 | 0.935 | 1.295 | 19 | 0.979 | 0.502 | 2.373 |
| VCinc (L) | 6 | 0.681 | 0.437 | 0.960 | 19 | 0.637 | 0.324 | 1.153 |
| Vind (L) | 6 | 0.633 | 0.388 | 0.903 | 19 | 0.465 | 0.255 | 1.022 |
| PIFe (L/sec) | 6 | 1.015 | 0.600 | 1.900 | 19 | 1.000 | 0.540 | 2.140 |
aTime span between pressing the dose-release button and start of inhalation, with negative Delta indicating early release; bTotal duration of inhalation; cTotal inhaled volume; dVolume inhaled during 1.5 sec after the release of the dose; ePeak inspiratory flow rate observed in the flow profiles during inhalation.