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Disruptive potential of small molecules against Hsp90β-p50Cdc37 complexes determined by ELISA.
| Complex | IC50 (µM) | ||||||
|---|---|---|---|---|---|---|---|
| ADP | ATP | AMP-PNP | H2-GMZ | H2-GMZ | Gedunin | NVP | |
| Hsp90-p50Cdc37 | 500 ± 94 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 |
| (p)Hsp90-p50Cdc37 | 220 ± 24 | 450 ± 150 | >1000 | >1000 | >1000 | >1000 | >1000 |
| Hsp90-(p)p50Cdc37 | 270 ± 35 | >1000 | n/d | n/d | n/d | n/d | n/d |
| (p)Hsp90-(p)p50Cdc37 | 32 ± 5.6 | 230 ± 40 | >1000 | >1000 | >1000 | >1000 | >1000 |
| ΔHsp90-p50Cdc37 | 400 ± 81 | >1000 | >1000 | >1000 | >1000 | >1000 | >1000 |
