Table 1.
Demographic characteristics and ACTA2 mutations of the study population and groups with and without aortic events.
| Variable | All (n= 277) | With aortic events (n= 132) | Without aortic events (n= 145) | p value |
|---|---|---|---|---|
| Median age (IQR) | 34 (20–49) | 34.5 (24–45) | 34 (15–55) | 0.995 |
| Gender | 0.003 | |||
| Male | 146 (52.7%) | 82 (62.1%) | 64 (44.1%) | |
| Female | 131 (47.3%) | 50 (37.9%) | 81 (55.9%) | |
| Race | 0.03 | |||
| Caucasian | 220 (79.4%) | 112 (84.8%) | 108 (74.5%) | |
| Non-Caucasian | 57 (20.6%) | 20 (15.2%) | 37 (25.5%) | |
| ACTA2 substitutions | ||||
| p.R149C | 69 (24.9%) | 33 (25%) | 36 (24.8%) | 0.97 |
| p.R39 | 28 (10.1%) | 13 (9.8%) | 15 (10.3%) | 0.89 |
| p.R258 | 23 (8.3%) | 15 (5.4%) | 8 (5.5%) | 0.08 |
| p.R179 | 20 (7.2%) | 7 (5.3%) | 13 (9.0%) | 0.24 |
| p.R212Q | 16 (5.8%) | 6 (4.5%) | 10 (6.9%) | 0.4 |
| p.R118Q | 14 (5.0%) | 8 (6.1%) | 6 (4.1%) | 0.47 |
| p.G160D | 9 (3.2%) | 4 (3%) | 5 (3.4%) | 0.84 |
| p.R185Q | 9 (3.2%) | 2 (1.5%) | 7 (4.8%) | 0.12 |
| Other mutations | 89 (32.1%) | 44 (33.3%) | 45 (31.0%) | 0.68 |