. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Circ Cardiovasc Genet. 2015 Mar 10;8(3):457–464. doi: 10.1161/CIRCGENETICS.114.000943

Table 3.

Comparison of aortic disease presentation among individuals with FBN1, TGFBR2, and ACTA2 mutations.

Variable	FBN1	TGFBR2	ACTA2
Number of individuals	243	71	277
Mean age	30±16	29±17	38±20
Number of probands	122	26	81
Percent of probands ascertained due to TAAD	36%	65%	84%
With aortic event^*	74 (30%)	25 (35%)	132 (48%)
Thoracic aortic dissection	31 (42%)	13 (52%)	116 (88%)
Type A	23 (31%); 39±9	10 (40%); 38±12	71 (54%); 36±12
Type B	8 (11%); 44±10	3 (12%); 34±6	28 (21%); 29±12
Aneurysm repair	43 (58%); 39±13	12 (48%); 35±16	16 (12%); 33±18
Without aortic event	169 (70%)	46 (65%)	145 (52%)
Ascending aortic aneurysm	135 (80%)	42 (91%)	25 (17%)

Frequency of aortic event or diagnosis and mean age ± standard deviation are provided.