Table 2.

Hazard ratios of renal outcomes in patients with V15.81 code using unadjusted analysis and various adjusted models

Analysis	Faster slope of eGFR decline HR with 95% CI*, p-value	Incident CKD HR with 95% CI*, p-value	ESRD HR with 95% CI*, p-value
Unadjusted analysis	1.22 (1.12-1.32), <0.001	1.17 (1.08-1.27), <0.001	2.53 (1.72-3.72), <0.001
Adjusted analysis #1	1.20 (1.10-1.32), <0.001	1.50 (1.38-1.63), <0.001	2.19 (1.44-3.34), <0.001
Adjusted analysis #2	1.14 (1.04-1.25), 0.006	1.53 (1.41-1.67), <0.001	2.22 (1.46-3.39), <0.001
Adjusted analysis #3	1.07 (0.98-1.17), 0.1	1.33 (1.22-1.45), <0.001	1.81 (1.18-2.78), 0.006
Adjusted analysis #4	1.07 (0.97-1.17), 0.2	1.33 (1.22-1.45), <0.001	1.81 (1.18-2.78), 0.007
Adjusted analysis #5	1.11 (0.98-1.26), 0.09	1.21 (1.08-1.36), 0.002	1.91 (1.13-3.23), 0.015

Footnotes: V15.81“-” group served as a reference group for all analyzes; HR, hazard ratio; CI, confidence interval; ESRD, end stage kidney disease; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; Adjusted analysis 1, adjusted analysis for age, gender, race, mean income, marital status, area-level housing stress, low education, low employment and persistent poverty; Adjusted analysis 2, adjusted analysis 1 plus estimated glomerular filtration rate (eGFR); Adjusted analysis 3, adjusted analysis 2 plus baseline comorbidities; Adjusted analysis 4, adjusted analysis 3 plus baseline systolic and diastolic blood pressure and body mass index. Adjusted analysis 5, adjusted analysis 4 plus adherence to antihypertensive drugs.