Table 3.
Discovery and Replication Results of rs1150711 and rs2859365 in Schizophrenia Samples Comprising a Total of 44123 Individuals
| SNP ID | Sample (cases) | Allelea | ORb | P valuec | |
|---|---|---|---|---|---|
| EA | OA | ||||
| rs2859365 | European sample (1420) | A | G | 1.030 | 0.659 |
| Asian sample (1222) | A | G | 1.077 | 0.266 | |
| African sample (644) | A | G | 1.008 | 0.941 | |
| German sample (1332) | A | G | 1.155 | 0.025 | |
| Danish sample 1 (876) | A | G | 0.964 | 0.609 | |
| Danish sample 2 (859) | A | G | 1.027 | 0.702 | |
| Combined replication (6353) | A | G | 1.047 | 0.111 | |
| PGC1 + SWE (13833) | A | G | 1.095 | 2.07×10–7 | |
| Overall combined (20 186) | A | G | 1.082 | 1.40×10–7 | |
| rs1150711 | European sample (1420) | T | C | 1.109 | 0.140 |
| Asian sample (1222) | T | C | 1.057 | 0.413 | |
| African sample (644) | T | C | 1.134 | 0.329 | |
| German sample (1332) | T | C | 1.209 | 0.007 | |
| Danish sample 1 (876) | T | C | 0.920 | 0.289 | |
| Danish sample 2 (859) | T | C | 1.009 | 0.908 | |
| Combined replication (6353) | T | C | 1.068 | 0.037 | |
| PGC1 + SWE (13833) | T | C | 1.119 | 2.76×10–9 | |
| Overall combined (20 186) | T | C | 1.105 | 6.85×10−10 | |
Boldface letters and italics were used to highlight the genetic variants that we are interested in.
aEA: effect allele, OA: other allele.
bOR (odds ratio) is based on effect allele.
cTwo-tailed P values. Combined analyses are based on a fixed effects meta-analysis of individual study results.