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. 2015 Apr 22;41(6):1349–1359. doi: 10.1093/schbul/sbv048

Fig. 1.

Fig. 1.

Neuropsychological functioning and brain volumes in individuals with a psychotic disorder. Top panel: Individuals with psychosis were classified into neuropsychologically (NP) normal and NP impaired groups based on their premorbid intellect and current NP functioning, and compared to healthy subjects on intracranial volume (ICV), total brain volume (TBV), and ICV adjusted TBV. ICV and TBV were reduced in NP impaired patients. After adjusting for ICV, mean TBV was lower in both NP impaired and NP normal patients. Bottom panel: Follow-up analysis after dividing the NP impaired group into deteriorated (ie, average premorbid IQ, impaired current NP functioning) and compromised (ie, below average premorbid IQ, impaired current NP functioning) groups revealed that reduced ICV in NP impaired patients was specific to the compromised subgroup; deteriorated patients did not differ from healthy subjects and NP normal patients. Absolute TBV was lowest in compromised patients; however, after adjusting for ICV, mean TBV in the compromised group did not differ from healthy subjects. In contrast, relative TBV was reduced in deteriorated patients compared to healthy subjects. Error bars = standard error of the mean.