Fig. 3.

Regional brain volume abnormalities in individuals with a psychotic disorder classified on the basis of neuropsychological (NP) functioning. Top panel: Grey and white matter volume loss was qualitatively more extensive in NP impaired psychosis patients. Specifically, NP impaired patients exhibited grey matter volume loss in the superior temporal gyrus, frontal lobe, thalamus, hippocampus/entorhinal cortex, and cerebellum, and extensive white matter volume loss, particularly in periventricular regions and body/splenium of the corpus callosum. Brain tissue volume loss in NP normal patients was restricted to anterior and posterior periventricular areas, and genu of the corpus callosum. Ventricular enlargement was detected in both NP normal and impaired psychosis patients. Bottom panel: Among NP impaired patients, grey matter volume loss was present in both groups; however, white matter volume loss was more widespread in the deteriorated subgroup. Ventricular enlargement was detected in both deteriorated and compromised subgroups.