Table 2.
Metabolic Outcomes: Estimated Least Squares Means and SE
| Measure | Condition | Baseline | SE | Week 4 | SE | Week 8 | SE | Week 12 | SE | Treatment- by-Time Interaction |
|---|---|---|---|---|---|---|---|---|---|---|
| Total cholesterol (mg/dl) | F = 4.73, df = 3,376, P = .003 | |||||||||
| Aripiprazole | 158.25 | 3.15 | 157.81* | 3.41 | 162.98* | 3.74 | 163.02** | 3.74 | ||
| Risperidone | 157.01 | 3.30 | 168.62* | 3.62 | 175.92* | 3.77 | 178.36** | 4.10 | ||
| LDL cholesterol (mg/dl) | F = 4.36, df = 3,369, P < .01 | |||||||||
| Aripiprazole | 86.37 | 2.60 | 84.97* | 2.78 | 90.31** | 3.02 | 91.89** | 3.02 | ||
| Risperidone | 88.25 | 2.77 | 95.49* | 3.02 | 104.10** | 3.14 | 105.62** | 3.41 | ||
| HDL cholesterol (mg/dl) | F = 0.83, df = 3,372, P = .48 | |||||||||
| Aripiprazole | 55.99 | 1.37 | 56.59 | 1.47 | 56.25 | 1.60 | 55.14 | 1.60 | ||
| Risperidone | 53.23 | 1.40 | 56.60 | 1.52 | 55.05 | 1.57 | 54.21 | 1.69 | ||
| Triglycerides (mg/dl) | F = 0.66, df = 3,352, P = .59a | |||||||||
| Aripiprazole | 80.00 | 4.48 | 80.78 | 4.90 | 87.52 | 5.44 | 87.35 | 5.44 | ||
| Risperidone | 77.41 | 4.50 | 86.12 | 4.96 | 88.24 | 5.17 | 93.17 | 5.64 | ||
| Fasting glucose (mg/dl) | F = 3.18, df = 3,367, P = .03 | |||||||||
| Aripiprazole | 85.06 | 0.69 | 86.26 | 0.76 | 87.18 | 0.87 | 84.22** | 0.89 | ||
| Risperidone | 84.60 | 0.89 | 85.81 | 1.03 | 86.61 | 1.09 | 88.24** | 1.22 | ||
| Fasting insulin (uU/ml) | F = 0.59, df = 3,372, P = .63 | |||||||||
| Aripiprazole | 12.39 | 1.10 | 13.06 | 1.23 | 13.79 | 1.40 | 14.65 | 1.39 | ||
| Risperidone | 13.10 | 1.38 | 12.60 | 1.54 | 14.14 | 1.67 | 12.18 | 1.85 | ||
| Prolactin (ng/ml) | ||||||||||
| Female participants | Aripiprazole | 61.84 | 7.61 | 11.58*** | 8.41 | 12.11*** | 8.97 | 9.72** | 11.60 | F = 11.62, df = 3,52.8, P < .0001 |
| Risperidone | 65.52 | 12.88 | 129.49*** | 14.45 | 103.50*** | 15.25 | 101.18** | 20.81 | ||
| Male participants | Aripiprazole | 28.72 | 3.05 | 9.05*** | 3.21 | 10.92*** | 3.67 | 6.59*** | 4.56 | F = 34.13, df = 3,205, P < .0001 |
| Risperidone | 31.50 | 3.24 | 54.52*** | 3.70 | 63.06*** | 4.00 | 54.23*** | 4.60 |
Note: HDL, high-density lipoprotein; LDL, low-density lipoprotein.
aMain effect of time F = 3.84, df = 3,352, P = .01.
*Difference between treatments, P < .05, **P < .01, ***P < .0001.