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. 2015 Oct 12;10(10):e0138702. doi: 10.1371/journal.pone.0138702

Table 3. Mean apparent diffusion coefficient (ADC) values (× 10−3 mm2s-1) of 3.0-Tesla using MRI from normal parenchyma, benign lesions, and malignant lesions, and ADC values’ utility in tumor characterization.

A review of the literature.

Bogner et al (2009) Cakir et al (2013) Park et al (2015) Dong et al (2014) Nogueira et al (2014)
Field strength and manufacturer 3T (Siemens) 3T (Philips) 3T (Siemens) 3T (GE) 3T (Siemens)
N 51 52 110 87 53
B values (mm2s-1) 500, 850 0, 50, 850, 1000, 1500; lower b range 0–1000 and higher b range 0–1500 0, 100 0, 800 50, 200, 400, 600, 800, 1000, 2000, 3000
MRI sequence order DWI prior to DCE DWI prior to DCE UN UN DWI prior to DCE
ROI type and placement Three-dimensional large ROI, avoiding fatty and necrotic tissue Average of automatic double reading; having two combined b values; excluding hemorrhagic, cystic, and necrotic areas Average of manual reading repeated 2–5 times; having two combined values; excluding hemorrhagic, cystic, and necrotic areas Mean value of 3 round ROIs avoiding necrosis and hemorrhage, size 10 to 20 mm2 ROI placed on the area of highest hyperintensity on DCE, size 10 mm2
ADC breast parenchyma 1.87±0.22 Lower: 1.66±0.34, higher: 1.48±0.30 1.51±0.29 1.696 1.99±0.27
ADC benign lesion 1.51±0.22 Lower: 1.27±0.37, higher: 1.20±0.40 1.41±0.56 NS 1.71±0.35
ADC malignant tumor 0.99±0.18 Lower: 0.82±0.07 and b range 0–1500: 0.82±0.08 0.88±0.15 1.065 1.08±0.25
ADC cut-off for malignancy 1.25 b range 0–1000: 1.23, higher 1.12 NS NS 1.41
Sensitivity (%) 96 Lower: 92.9, higher: 96.2 NS NS 94.3
Specificity (%) 94 Lower: 54.5, higher: 59.1 NS NS 87.5
Positive Predictive Value (%) NS Lower: 72.2, higher73.5 NS NS 91.7
Negative Predictive Value (%) NS Lower: 85.7, higher: 92.9 NS NS 91.3
Accuracy (%) 95 NS NS NS 91.5

T = tesla

ROI = region of interest

N = number of patients

NS = not studied

DWI = diffusion-weighted imaging sequence

DCE = dynamic contrast-enhanced imaging sequence

UN = unspecified.