Table 1. Characteristics of the MESA-Inflammation study population by type 2 diabetes status.
| MESA-Inflammation | |||
|---|---|---|---|
| Variable | Non-Diabetic (n = 775) | T2D (n = 154) | P-value |
| Age, years (mean, SD) | 65.4 (10.0) | 66.9 (9.5) | 0.09 |
| Men (n, %) | 363 (47) | 84 (55) | 0.08 |
| Ethnicity (n, %) | 0.002 | ||
| European-American | 355 (46) | 49 (32) | |
| African-American | 198 (25) | 38 (25) | |
| Hispanic-American | 146 (19) | 45 (29) | |
| Chinese-American | 76 (10) | 22 (14) | |
| Waist Circumference, cm (mean, SD) | 97.7 (13.8) | 109.1 (16.4) | <0.0001 |
| BMI, kg/m2 (mean, SD) | 28.0 (5.1) | 32.0 (6.7) | <0.0001 |
| Smoking Status (n, %) | 0.78 | ||
| Never | 342 (44) | 67 (44) | |
| Former | 356 (46) | 74 (48) | |
| Current | 73 (10) | 12 (8) | |
| Hypertension Status (n, %) | <0.0001 | ||
| Normal | 412 (54) | 43 (28) | |
| Hypertensive (takes medications) | 349 (46) | 108 (72) | |
| Glucose, mmol/L (median, 25th, 75th) | 5.2 (4.8, 5.6) | 7.1 (6.0, 8.5) | <0.0001 |
| Impaired Fasting Glucose (n, %) | 196 (21) | n/a | n/a |
| HbA1c*, % (median, 25th, 75th) | 5.6 (5.5, 5.9) | 6.7 (6.2, 7.4) | <0.0001 |
| Insulin*, pmol/L (median, 25th, 75th) | 329.9 (208.4, 507.0) | 427.1 (291.7, 701.4) | 0.0001 |
| Takes Diabetes Medication (n, %) | n/a | 134 (87) | n/a |
| Clinical CVD (n, %) ** | 40 (5) | 13 (8) | 0.11 |
| Lymphocyte Indices | |||
| %Natural Killer (mean, SD) | 8.3 (5.2) | 8.8 (5.6) | 0.26 |
| %γδ T (median, 25th, 75th) | 1.7 (0.97, 3.0) | 1.6 (0.99, 2.5) | 0.87 |
| %CD4 Naive (mean, SD) | 29.0 (14.3) | 24.6 (13.3) | 0.0004 |
| %CD4 Memory (mean, SD) | 53.3 (15.0) | 57.2 (15.5) | 0.003 |
| %Th1 (mean, SD) | 15.8 (8.2) | 16.6 (8.5) | 0.28 |
| %Th2 (mean, SD) | 0.83 (0.70) | 0.86 (0.65) | 0.66 |
Data are from MESA exam 4 (2005–2007) unless otherwise noted.
*: Data are from MESA exam 5 (2010–2012).
**: Includes all participants with incident cardiovascular events (myocardial infarction, resuscitated cardiac arrest, definite or probable angina, and stroke) from baseline through the start of MESA exam 4.