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. 2015 Apr 15;212(9):1429–1438. doi: 10.1093/infdis/jiv224

Figure 2.

Figure 2.

Comparison of malaria antigen-specific antibody (Ab) responses of adults and children. A, Ab responses by adults (≥18 years old) and children 1–5 years old, sorted from left to right on the x-axis according to progressively decreasing signal intensity generated by adult Abs. Reactive antigens were defined by the mean signal intensity against the background (pixel intensity with no-DNA control signals subtracted) of Abs from adults greater than the mean plus 2 standard deviations of the no-DNA controls. Of 824 Plasmodium falciparum antigens on the array, 163 were reactive above the cutoff. Significant Benjamini-Hochberg (BH)–corrected P values (<.05) for adults versus 1–5-year-old children are shown in green for the comparison. B, Scatterplot of mean Ab signal intensities to 163 P. falciparum antigens from each age group of children (y-axis) against the mean intensities for adults (x-axis). C, Comparison of mean Ab signal intensities of Kenyan adults and children according to age group and malaria-naive adults from the United States. Kruskal–Wallis/Dunn multiple-comparison tests were performed with BH-corrected P values to compare the groups.