Table 3.

Major and minor risk factors used during host stratification. A patient with one major or three (or more) minor risk factors was considered to be a C-host.

Major risk factors	Minor systemic risk factors	Minor local risk factors
CD4 count <350 cells/mm3	HIV infection	Poor soft tissues requiring flap
Albumin <30 g/L	Anemia	Chronic venous insufficiency
HbA1C ≥ 8%	Smoking	Peripheral vascular disease
Cellulitis or abscess formation	Diabetes mellitus	Previous radiation therapy
Malignancy at site of infection	Rheumatoid Arthritis	Surgery will result in instability
Pathological fracture	Chronic lung disease	Adjacent joint stiff/arthritic
Chronic cardiac failure	Heterotopic ossification
Common variable immune deficiency	Segmental resection of ≥6 cm required to achieve cure
Paraplegia/Quadriplegia
Drug or substance abuse
Chronic corticosteroid use
Active tuberculosis
Ischemic heart disease
Cerebrovascular disease