Table 3.

Trials on endovascular treatment of anterior circulation stroke: clinical outcome in relation to baseline NIHSS score and endovascular techniques applied

Study designation	Number of patients undergoing endovascular treatment	Baseline NIHSS score, median	Favorable outcome (mRS score 0–2) at 3 months (%)	Endovascular techniques applied
PROACT II [18]	121	17	40	ia prourokinase
MELT [9]	57	14	49	ia urokinase
Mattle et al. [26]	55	17a	53	ia urokinase
Galimanis et al. [31]	623	15	49	ia urokinase, aspiration, stent retriever (Solitaire)
Multi MERCI trial [7]	164	19	36	Distal Thrombectomy (Merci)
Penumbra trial [6]	125	18a	25	Fragmentation/aspiration (Penumbra)
SWIFT [10]
- Merci	58	18	28	Merci
- Solitaire	55	17	37	Solitaire (protection not mandatory)
TREVO 2 [5]
- Merci	90	18	22	Merci
- TREVO	88	19	40	Stent retriever (Trevo, protection not mandatory)
MR CLEAN [1]	233	17	33	ia alteplase or urokinase, thrombus retraction, aspiration, wire disruption, stent retriever (protection not mandatory)
IMS III [15]	434	17	41	Merci, Penumbra, Solitaire (protection not mandatory), ia tPA
MR RESCUE [16]	64	16 (penumbral), 19 (non-penumbral	19	Merci, Penumbra, ia tPA
SYNTHESIS [17]	181	13	42	ia tPA, wire disruption, Merci, Penumbra, Trevo, Solitaire (protection not mandatory)
Dávalos et al. [2]	141	18	55	Solitaire (protection in 74 % of interventions)
STAR trial [3]	202	17	58	Solitaire (protection mandatory)
ESCAPE trial [11]	165	16	53	Stent retriever recommended (protection recommended)
EXTEND-IA trial [12]	35	17	71	Solitaire (protection mandatory)
REVASCAT [13]	103	17	44	Solitaire (protection not mandatory)
SWIFT prime [14]	98	17	60	Solitaire (protection mandatory)

ia intraarterial, NIHSS NIH Stroke Scale, mRS modified Rankin Scale

^aMean