Table 1.
miRNA profiling in experimental model.
| Model | Stage (Time point) | Platform | Aberrantly expressed miRNAs | Regulation | References |
|---|---|---|---|---|---|
| KA SzPc (mouse) | Acute (8 h) | TaqMan | miR-148b, -376a, -335, -9, -129, -132, -34c, -369-3p, -204, -299-5p, -30a-3p, -7, -34b, -409-5p, -29a, -100, -184, -448, -28, -140, -29c, -375, -31, -130b, let-7f | Up | McKiernan et al., 2012 |
| KA (rat) | Acute (24 h) | TaqMan | miR-298 | Up | Liu et al., 2010 |
| miR-155, -29c, -34b-3p, -98, -122, -203, -450a | Down | ||||
| PILO (rat) | Acute (24 h) | Microarray (Agilent) | miR-213, -132, -30c, -26a, -375, -99a, -24, -124a, -22, -34a, -125a, -101-1, -29b, -125b, -199a, -196b, -150, -151, -145 | Up | Hu et al., 2011 |
| miR-29a, -181c, -215, -181b, -25, -10b, -21 | Down | ||||
| KA SzPc (mouse) | Acute (24 h) | Taqman | miR-10b, -21, -29a, -30e, -125a, -132, -134, -139, -146b, -153, -181c, -199a, -219, -323, -328, -375, -425, -451, -487b, -507, -509, -518d, -532 | Up | Jimenez-Mateos et al., 2011 |
| miR-27a, -101, -103, -107, -127, -133b, -145, -148b, -200a, -326, -330, -374, -381, -422b, -497, -520b, -657 | Down | ||||
| KA SzPc (mouse) | Acute (24 h) | Taqman | miR-10b, -21, -27a -29a, -30e, -101, -103, -107, -125a, -127, -132,-134, -139, -145, -146b, -148b, -153, -181c, -199a, -200a, -219, -323, -326, -328, -375, -425, -451, -487b, -507, -509, -518d, -532, -629 | Up | Jimenez-Mateos et al., 2011 |
| miR-133b, -330, -374, -381, -422b, -497, -520b, -657 | Down | ||||
| PILO (mouse) | Acute (24 h) | Microarray (Exiqon) | miR-2137, -21-5p, -711, -212-3p, -882, -1947-5p, -21-3p, -142-5p, -467d-5p, -132-3p, -710, -712-5p, -223-3p, -142-3p, -706, -691, -294-5p, -709, -22-3p, -29a-3p, -431-5p, -126-3p, -29b-1-5p, -483-3p, -29b-3p, -1892, -1957, let-7a-5p, -23a-3p, let-7e-5p, -1935, -19a-3p, -494-3p, -24-2-5p, -335-3p, -146b-5p, -203-3p, -875-3p, -1983, -1897-5p, -17-5p, -146a-5p, -1895, -290-5p, -674-5p | Up | Kretschmann et al., 2015 |
| miR-331-3p, let-7d-3p, -181c-5p, -324-5p, let-7b-3p, -194-5p, -409-5p, -125b-2-3p, -1941-3p, -467d-3p, -433-3p, -30a-5p, -149-5p, -668-3p, -873-5p, -181d-5p, -467e-5p, -181b-5p, -466d-3p, -761, -1839-3p, -124-5p, -186-5p, -224-5p, -218-2-3p, -881-3p, -330-5p, -491-5p, -337-5p, -380-3p, -542-3p, -361-5p, -181a-1-3p, -669h-3p, -449b, -1224-5p, -374-5p/, -374c-5p, -466c-5p, -208a-3p, -425-3p, -466g, -760-3p, -673-5p, -301b-3p, -742-3p, -488-5p, -216b-5p, -499-5p, -1b-5p, -211-5p, -703, -339-3p, -466l-3p, -302b-5p | Down | ||||
| ES (rat) | (7–90 d) | Microarray (Exiqon) | miR-212-3p, -132-3p, -21-5p, -132-5p, -212-5p, -146a-5p, -23a-3p, -370-5p | Up | Bot et al., 2013 |
| miR-344b-2-3p,-345-5p, -322-5p, -124-5p, -291a-5p, -7a-2-3p, -138-2-3p, -330-3p, -128-3p, -664-3p, -383-5p, -29b-2-5p, -7a-1-3p, -205, -1843-3p, -497-5p, -29c-3p, -7b, -138-1-3p, -505-3p, -30a-3p, -1843-5p, -743a-5p, -186-5p, -103-3p, -324-5p, -324-3p, -124-3p, -330-5p, -582-5p, -107-3p, -146b-5p, -148b-3p, -335, -301a-3p, -29a-5p, -30b-5p, -935, -130a-3p, -190a-5p, -31a-5p, -3580-3p, -29c-5p, -9b-5p, -26a-5p, -218a-5p, -137-3p, -708-5p, -101a-3p, -30a-5p, -33-5p, -30d-5p, -139-5p, -374-5p, -30e-5p, -7a-5p, -551b-3p, -187-3p | Down | ||||
| ES (rat) | Latent (7 d) | Microarray (Exiqon) | miR-21-5p*, -212-3p, -132-3p, -370-5p* | Up | Bot et al., 2013 |
| miR-7a-2-3p, let-7d-3p, -1843-5p, -1843-5p, -124-3p, -301a-3p, -324-5p, -29a-5p, -708-5p, -935, -92b-3p, -374-5p*, -328a-3p, -139-5p, -30d-5p, -33-5p* -187-3p*, -551b-3p, -7a-5p | Down | ||||
| PILO (mouse) | Chronic (28 d) | Microarray (Exiqon) | miR-135b-5p, -132-3p, -199a-5p, -23a-3p, -129-5p, -129-2-3p, -669c-5p, -467e-5p, -212-3p, -203-3p, -467c-3p, -467e-3p, -455-3p, -466f-3p, -669f-3p, -222-3p, -297c-5p, -27a-3p, -297a-5p, -467g, -22-5p, -494-3p | Up | Kretschmann et al., 2015 |
| miR-325-3p, -345-5p, -1949, let-7f-1-3p, -191-5p, -350-3p, -331-3p, -875-3p, -138-1-3p, -181a-5p, -34b-3p, -409-5p, -338-5p, -676-3p, -187-3p, -551b-3p, -674-5p, -194-5p, -324-5p, let-7d-3p, -210-3p, -140-3p, -298-5p, -130a-3p, -29b-1-5p, -92b-3p, -330-3p, -431-3p, -767 | Down | ||||
| ES (rat) | Chronic (30 d) | Microarray (Exiqon) | miR-146a-5p, -132-5p, -21-5p*, -212-5p, -23a-3p, -34a-5p, -370-5p*, -34b-5p, -24-2-5p, -433-3p, -34c-5p | Up | Bot et al., 2013 |
| miR-29c-5p, -30a-5p, -374-5p*, -33-5p*, -218a-5p, -187-3p*, -30e-5p, -352, -29b-3p | Down | ||||
| PILO (rat) | Chronic (60 d) | Microarray (μParaflo) | miR-99a, -134, -127, -379, -137, -324-5p, -27b, -383, -132, -24, -29a, -139-5p, -9*, -23b, -146a, -140*, -23a, -126 | Up | Song et al., 2011 |
| miR-98, -352, let-7e, -185, let-7d | Down | ||||
| PILO (rat) | Chronic (60 d) | Microarray (Agilent) | miR-146a, -211, -203, -210, -152, -31, -23a, -34a, -27a | Up | Hu et al., 2012a |
| miR-138, -301a, -136, -153, -19a, -135b, -325-5p, -380, -190, -542-3p, -33, -144, -542-5p, -543, -296 | Down | ||||
| ES (rat) | Chronic (60 d) | NGS | miR-455-3p, -345-3p, -423-3p, -54, -365-5p, | Up | Li et al., 2014 |
| miR-296-5p | Down | ||||
| ES (rat) | Chronic (3–4 m) | Microarray (Exiqon) | miR-126, -126*, -129, -129-2*, -132, -132*, -135a, -140, -140*, -143, -144, -145, -146a, -152, -199a-3p, -199a-5p, -204, -21, -210, -212, -212*, -214, -223, -23a, -23b, -24, -24-1*, -24-2*, -27a, -27b, -322, -34a, -34b, -34c, -378, -451, -542-3p | Up | Gorter et al., 2014 |
| miR-139-5p, -187, -218a, -551b, -935 | Down | ||||
| PILO (rat) | Acute (4 h) | Microarray (Exicon) | miR-132, -184, -214, -516b, -470, -518c*, -519e*, -519c-5p, -503, -M1-4, -583, -BART8*, -637, -M1-8, -K12-6-3p, -S1-5p, -713, -658, -K12-8, -467b*, -132*, -934, -125b-1*, -193a-5p, -21*, -185*, -183*, miRPlus_27560, -423-5p, -711-765, Plus_28431, -675-5p, -498, -883a-5p, -149*, Plus_42487, -516a-5p, -miR-881*, -212, -885-3p, -483-5p, -642, -485-3p, -625*, -30c-2*, -371-5p, Plus_42745, -187*, -921, Plus_42793, -300*, -638, -882, ebv-miR-BHRF1-1, -25*, -193b*, -300, -763, -294*, -518a-5p, -551a, -198, -204* | Up | Risbud and Porter, 2013 |
| ND | Down | ||||
| PILO (rat) | Acute (48 h) | Microarray (Exicon) | miR-21, -155, -M1-8, -685, -S1-5p, -_SNORD3@, -881*, -483-5p, Plus_42793, -300 | Up | Risbud and Porter, 2013 |
| miR-9, -126, let-7i, -130a, let-7d, -103, -107, -125a-5p -137, -148a -154, -181b, -191, -181a* -218, -22, -221, -222, -26a, -299-5p, -29b -29c, -30a,-376b, -377, -382, -378, -503, -519d, -519e, -98, -99b, -207, -300, -30e*, -329, -345-5p, -380-3p, -433*, -434-3p, -434-5p, -151-5p, -333, -336, -352, -450a, -7-1*, U6-snRNA-1, -138, -301a, -369-5p, -195, -322, -10a, -376a*, -539, -487b, -541, -29c*, -361-5p, -374b, -381, -664, -124, -411, -7-2*, -30b, -629*, -691, -92b, -let-7a, -let-7d, -let-7f, -let-7a*, miRPlus_17891, -99b*, -491-3p, -186, -450a, -let-7c, -let-7i, -100, -148b, -30a*, -let-7g, -742, -374a, -190, -139-5p, -363*, -744, -891a, -30e, -872, -741, -667, -let-7b, -9*, -768-5p, -340, -125b, -804, -384-3p, -342-3p, let-7f, -126*, -505, -382*, -376c*, -598, let-7e, let-7g, -485-5p, -181c, -136*, -22*, -933, -494, -589, -379*, -26b, -384, -634, -503*, -376c, -140-3p, -145, let-7c-1*, -505, -337-3p, -328, -495, -136*, -325, -99a, -887, -33a, -34b, -668, -138, let-7e* -872*, -665, -347, -125b*, -411*, -337-3p, -29b-2*, -582-5p, -150,-149, -218-2*, -597, -888*, -127-3p, -28-5p, -181d, -384-5p, -497, -433, miRPlus_42856, -743b, -181a, -337-5p, -138-1*, -331-3p, -875-3p, -379*, -467e*, -124*, -185, -327, -551b, -29a*, -30c, -409-5p, -582-3p, -134, -BART17-5p, -101b, -323-3p, -742, | Down | ||||
| PILO (rat) | Latent (3 w) | Microarray (Exicon) | miR-21, -142-3p, -155, -19a, -19b, -583, -BART8*, -685, -S1-5p, -K12-8, -193a-5p, Plus_17952, _SNORD2, -142-5p, -675-5p, -498, Plus_42487, -516a-5p, -20b, -106a, -20a, -17, -423-3p, -371-5p, -20b, -25*, -550, -34a | Up | Risbud and Porter, 2013 |
| miR-299-5p, -7-1*, -615-3p | Down | ||||
| PILO (rat) | Acute (2 h) | qPCR | miR-124, -134, -132,-21, -183, -135a, -125b, -27a, -9, -155, 30c | Up | Omran et al., 2012; Ashhab et al., 2013a,b; Peng et al., 2013; Alsharafi and Xiao, 2015 |
| miR-221, -222, -138, -181a, -128 | Down | ||||
| Latent (3 w) | miR-132, -146a, -27a | Up | |||
| miR-21, -221, -222, 30c | Down | ||||
| Chronic (60 d) | miR-124, -134, -132,-21, -183, -135a, -125b, 27a, -9, -146a, -155, -181a, -30c | Up | |||
| miR-138, -221,- 222, -128 | Down |
PILO, pilocarpine; KA, kainic acid; SE, status epilepticus; ES, Electrical stimulation; NGS, next-generation sequencing; SzPc, seizure preconditioning; ND, not detected.
*
means the passenger strand of the mature miRNA.