Table 2.
miRNA profile in human epilepsy.
| Patients | Specimen | Platform | Aberrantly expressed NAs | Regulation | References |
|---|---|---|---|---|---|
| mTLE | Hippo | Microarray (Exiqon) | miR-9, let-7f, -16, -17, -20a, -26b, -27a, -92b, -99a, -106a, -126, -129-3p, -135a, -190, -193a-3p, -195, -203, -301a, -340, -362-3p, -374a, -374b, -597, -625, -660, -1297 | Up | Kan et al., 2012 |
| miR-141, -146b-3p, -185,-214, -220c, -490-3p, -635, -637, -642, -665, -920, -934, -1255a, -1304, -1469, -1973, Plus-F1021, Plus-E1026, Plus-E1185, Plus-E1212, Plus-E1232 | Down | ||||
| TLE | Hippo/TL neocortex | Taqman | miR-133b, -182, -200c, -650, -380-5p, -594, -223, -501, -203, -451 | Up | McKiernan et al., 2012b |
| miR-181d, -130b-3p, let-7g, -411-5p, -335-5p, -210, -103a-3p, -23b-3p, let-7d, -25-3p, -340, -100-5p, -99a-5p, -27b-3p, -126-5p, -324-5p, -21-5p, -425, -92, -497-5p, -125b-5p, let-7f-5p, -187, -330-3p, -29c, -423, -130a-3p, -433, -95, let-7b-5p, -30d-5p, -106b-5p, -9*, -301a-3p, -30b-5p, -432-5p | Down | ||||
| DRE | HGC | Microarray (Agilent) | miR-1234, -1281, -30c-1*, -92b, -191*, -1238 | Up | Zucchini et al., 2014 |
| miR-3607-5p, -219-5p, -338-3p, -590-5p, -487a, -3659 | Down | ||||
| mTLE | Hippo | Microarray (Exiqon) | miR-302b, -432*, -299-3p, -501, -515-3p, -197, -502, -383, -183, -519d, -493, -338-5p, -10b, -184, -141, -375, -200a, -130b, -182, -193b, -361, -368, -519e*, -429, -199a, | Up | Kaalund et al., 2014 |
| miR-140*, -204, -211, -490, -218 | Down | ||||
| Epilepsy | Serum | NGS (Illumina) | miR-144-5p, -15a-5p, -181c-5p, -194-5p, -889-3p, -96 | Up | Wang et al., 2015a |
| let-7d-5p, -106b-5p, -130a-3p, -146a-5p | Down | ||||
| DRE | Serum | NGS (Illumina) | miR-574-5p, -67, novel -9 | Up | Wang et al., 2015b |
| miR-194-5p, -204-5p, -221-5p, -301a-3p, -30b-5p, -342-5p, -3605-5p, -4446-3p, -598-3p, -874-3p, -889-3p, novel-451 | Down | ||||
| mTLE | Hippo | qPCR | miR-183, -135a, -125b, -27a, -146a, -155, -9, 181a, 124, 134, -21, -132, -30c, | Up | Omran et al., 2012; Ashhab et al., 2013a,b; Peng et al., 2013; Alsharafi and Xiao, 2015 |
| miR-128, -138, -221, -222 | Down |
mTLE, mesial temporal lobe epilepsy; DRE, drug resistant epilepsy; Hippo, hippocampus; T.L., temporal lobe; HGC, hippocampal granule cells; NGS, next-generation sequencing.
*
means the passenger strand of the mature miRNA.