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. 2015 Oct 13;6:1102. doi: 10.3389/fmicb.2015.01102

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Copyright © 2015 Tóth, Alonso, Bain, Vágvölgyi, Erwig and Gácser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Engulfment time of GA1 and CLIB 214 by macrophages. Representative images show the full internalization of C. parapsilosis CLIB 214 (A, upper panel) and GA1 cells (A, lower panel) by human PBMC-derived macrophages. Numbers at the upper right corner of pictures show the time (minutes) of observed individual events. Arrows show the fungal cells internalized by phagocytes. Diagrams show the average time (mean-values + SD) in minutes required for the full ingestion of live or UV-treated GA1 and CLIB 214 cells by J774 (B) and PBMC-derived macrophages (C). One-way ANOVA analysis with Bonferroni's multiple comparison test was used to determine statistical significance. Significant differences were considered at p-values ^**p < 0.01; ^***p < 0.001. Scale bar: 20 μm.