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Comparative CO2 production (ppm/min) over 30 min induced by B12r antidote (hydroxocobalamin B12 +ascorbic acid) added to whole human blood containing 50% COHgb. The shaded area is the difference between CO2 produced from ascorbic acid alone, and that produced by B12r. Little or no CO2 was produced by infusion of normal saline (NS) or oxidized hydroxocobalamin.
